The first step of course is to install the node.js product.
I know I've seen pages that deal with this, and the first one I found was the following:
It seemed to be pretty inclusive, including how to connect to your IBM i database as well as run commands. What else could someone want?
I rummaged through my DVDs and CDs that came with our machine and found the 5733OPS disc and stuck it in the optical drive of our 41A machine. I then installed the licensed program and all the options:
Next is to install the required PTFs. Never fun, especially if you're not a operations/hardware guy like me. I actually spent 3 hours trying to figure out why my PTFs weren't applying (after countless IPLs) only to realize I was booting to the "A" side instead of the "B" side. New hardware... so much fun!
I then continued following the instructions in the above page and everything seemed to look fine.